A Case of Langerhans Cell Histiocytosis Presenting with Bilateral Otorrhea
-
- Chiba Makoto
- Yamagata University School of Medicine Yamagata Prefectural Shinjyo Hospital
-
- Ito Tsukasa
- Yamagata University School of Medicine
-
- Watanabe Tomoo
- Yamagata University School of Medicine
-
- Kubota Toshinori
- Yamagata University School of Medicine
-
- Ohta Nobuo
- Yamagata University School of Medicine
-
- Kakehata Seiji
- Yamagata University School of Medicine
-
- Aoyagi Masaru
- Yamagata Prefectural University of Health Sciences
Bibliographic Information
- Other Title
-
- 難治性耳漏を初発症状としたランゲルハンス細胞組織球症例
- 臨床 難治性耳漏を初発症状としたランゲルハンス細胞組織球症例
- リンショウ ナンチセイ ジロウ オ ショハツ ショウジョウ ト シタ ランゲルハンス サイボウ ソシキキュウ ショウレイ
Search this article
Abstract
Langerhans cell histiocytosis (LCH) involves the proliferation and accumulation of Langerhans cells at various sites and presents with various symptoms, depending on the organ or organs invaded.<br> A 2-year-old boy with LCH was treated at our hospital. Fever, head rash, bilateral chronic otorrhea unresponsive to antibiotics, and left exophthalmos were observed at our first examination. The CT scan showed destruction of the skull bone, zygomatic bone and vertebrae, and masses within these lesions. No bony defect was detectable in the middle ear, but a mass was present in the external auditory meatus. Skull X-rays revealed characteristic “punched-out” lesions. We confirmed the diagnosis of LCH with a biopsy of the head mass and the external auditory meatus mass. Immunohistology revealed positive staining of the lesional cells with CD1a and Langerin (CD207). The final diagnosis was multisystem LCH (MS-LCH). The child was placed on the chemotherapeutic regimen recommended by the Histiocyte Society.<br>
Journal
-
- Practica Oto-Rhino-Laryngologica
-
Practica Oto-Rhino-Laryngologica 106 (5), 417-422, 2013
The Society of Practical Otolaryngology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679249723904
-
- NII Article ID
- 10031166755
-
- NII Book ID
- AN00107089
-
- ISSN
- 18844545
- 00326313
-
- NDL BIB ID
- 024650740
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed