新向精神作用薬，ＣＳ‐４３０の中枢神経系に及ぼす影響

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  • Effects of a new psychotropic agent, CS-430, on the central nervous system of experimental animals.
  • シン コウ セイシン サヨウヤク CS-430 ノ チュウスウ シンケイケイ

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In rats and rabbits with chronically implanted electrodesCS-430(10-bromo-2, 3, 7, 1lb-tetrahydro-1lb-(2-ftuorophenyl)-oxazolo(3, 2d) [1, 4] benzodiazepine-6 (5H) -one) (3 mg/kg, p.o.) decreased the slightly awake period and increased the slow-wave sleep period. The onset time of sleep was significantly shortened. In the rat pre-treated with p-chlorophenylalanine (500 mg/kg, p.o.), the awake period was remarkably increased and the slow wave sleep period was considerably decreased at 48 hours after the pre-treatment. In these rats CS-430 given in the same dose decreased significantly the awake period and the onset time of sleep and increased the slow wave sleep period. CS-430 raised the threshold of the arousal response with stimulation of the posterior hypothalamus, but not of the mesencephalic reticular formation. These effects of CS-430 were almost as potent as those of nitrazepam (NZP). CS-430 reduced duration of after-discharges following stimulation of the hippocampus, depressed the decerebrate rigidity and inhibited activity of lumbar r-motoneurons in anesthetized cats. CS-430 (10 mg/kg, p.o.) inhibited the evoked responses recorded from the proreus gyrus following stimulation of either the baso-magnocellularis of the amygdaloid nucleus or the ventral hippocampus, although such did not inhibit the responses between the olfactory bulb and the pyriform cortex, the thalamus and the sensory-motor cortex. Thus CS-430 has a sleep-inducing effect in animals of almost the same potency as is seen with NZP, and site(s) of action in the limbic system appear to be specific.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 74 (7), 857-870, 1978

    公益社団法人 日本薬理学会

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