好酸球性中耳炎　その基礎と臨床

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  • 松原 篤
    弘前大学大学院医学研究科耳鼻咽喉科学講座

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タイトル別名
  • Eosinophilic Otitis Media: Basic Research and Clinical Manifestations
  • コウサンキュウセイ チュウジエン ソノ キソ ト リンショウ

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Intractable otitis media associated with bronchial asthma was first reported at the annual meeting of the Japan Otological Society held in 1992, and was named eosinophilic otitis media (EOM) by Dr. S. Matsutani in 1995. The most common characteristics of this disease is the presence of eosinophil-dominant highly viscous middle ear effusion. EOM is well-known to be associated with a high risk of hearing loss, and some cases have even been reported to develop deafness. Therefore, it is important to diagnose EOM early and provide appropriate treatment to ensure preserved hearing.<br>The pathological characteristics of EOM have been gradually revealed by both clinical research and basic research over the last two decades. Here, we report the clinical manifestations of EOM, and the data of basic research in the middle ear of human subjects and in inner ear specimens of an animal model constructed by us recently.

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