書誌事項
- タイトル別名
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- Effect of Y-25130, a selective 5-HT3 receptor antagonist, on the intestinal fluid secretion in rats.
- センタクテキ セロトニン 3 ジュヨウタイ キッコウヤク Y-25130 ノ
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We studied the effect of Y-25130 on the intestinal fluid secretion induced by 5-HT and cholera toxin in rats. 1) Net fluid secretion was increased dose-dependently by intramesenteric artery infusion of 5-HT (1 ?? 10 μg/ min). 2) Y-25130 (0.01 ?? 1 mg/kg, i.v.) inhibited the net fluid secretion induced by 5-HT (3 μg/min). Granisetron and ondansetron also inhibited the net fluid secretion induced by 5-HT. 3) Methysergide did not inhibit the fluid secretion, and neither atropine nor tetrodotoxin inhibited it. 4) Cholera toxin (1 ?? 10 μg/2 ml into jejunal loops) caused profuse net fluid secretion. 5) Y-25130 (1 mg/kg, i.v.) inhibited the net fluid secretion induced by cholera toxin (3 μg/2 ml). Granisetron was inhibitory and ondansetron tended to inhibit the cholera toxin-induced secretion. These results suggest that 5-HT may increase the net fluid secretion through 5-HT3 receptors, and cholera toxin-induced fluid secretion may be at least partially mediated by 5-HT3 receptors. It is expected that Y-25130 may be useful for treating secretory diarrhea in humans.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 101 (5), 299-307, 1993
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679249961344
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- NII論文ID
- 130000760149
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- NII書誌ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3831673
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- PubMed
- 8330800
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可