Effect of plaunotol on trinitrobenzene sulfonic acid and acetic acid induced colonic lesions in rats.

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  • MAKINO Mitsuko
    Pharmacology & Molecular Biology Research Laboratories, Sankyo Co., Ltd.
  • INOMATA Yuka
    Pharmacology & Molecular Biology Research Laboratories, Sankyo Co., Ltd.
  • ITO Keiichi
    Pharmacology & Molecular Biology Research Laboratories, Sankyo Co., Ltd.
  • TABATA Keiichi
    Licensing Department, Sankyo Co., Ltd.

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  • トリニトロベンゼンスルフォン酸および酢酸誘発ラット大腸炎モデルにおけるプラウノトールの効果
  • トリニトロベンゼンスルフォンサン オヨビ サクサン ユウハツ ラット ダイチョ

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Abstract

The aim of this study was to assess the effect of plaunotol, an anti-ulcer agent, on trinitrobenzene sulfonic acid (TNB)- and acetic acid-induced colonic lesions in rats. Plaunotol significantly reduced the severity of colonic mucosal lesions induced by TNB at a dose of 600 mg/kg/day. Moreover, plaunotol, at a dose of 600 mg/kg/day, significantly depressed the myeloperoxidase activity of the lesioned area induced by TNB of the rat colon. In the model of colitis induced by acetic acid, plaunotol reduced the area of lesions dosedependently and significantly at doses of 60, 200 and 600 mg/kg/day as asessed by macroscopic observation. Microscopic observation showed obvious changes by administration of plaunotol such as reduction of epithelial cell necrosis, decreased mucin production and a decreased infiltration of a large number of neutrophils. In conclusion, plaunotol showed a protective effect against colonic lesion formation induced by TNB and acetic acid in rats. This study suggests the possibility that plaunotol may be effective and useful for treatment of inflammatory bowel disease in humans.

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