The life cycle of the GABAA receptor and its regulating molecules.

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  • KANEMATSU Takashi
    Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University
  • TERUNUMA Miho
    Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University
  • GOTO Hidefumi
    Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University
  • KURATANI Akiko
    Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University
  • HIRATA Masato
    Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University

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  • ＧＡＢＡＡ受容体の一生とそれを調節する分子達
  • GABAA ジュヨウタイ ノ イッショウ ト ソレ オ チョウセツ スル ブンシ タチ

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γ-Aminobutyric acidA (GABAA) receptors mediate most of the fast inhibitory neurotransmission in the central nervous system. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. This review highlights recent findings on the regulation of GABAA-receptor expression and function, focusing on the mechanisms of sorting, targeting, synaptic clustering, and endocytic events of GABAA receptors, all which are regulated by their associated proteins. Now these topics are an area of active interest in studies on inhibitory neurotransmission.<br>

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