妊娠末期家とにおけるデヒドロエピアンドロステロンサルフェートの血清中ステロイドホルモンにおよぼす影響

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書誌事項

タイトル別名
  • Effects of dehydroepiandrosterone sulfate on serum steroid hormones in pregnant rabbits
  • ニンシン マッキ カト ニ オケル Dehydroepiandrosteron

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抄録

After the administration of dehydroepiandrosterone sulfate (DHAS) (0, 10, 30, 70 mg/kg, i.v.) to rabbits during late pregnancy, serum concentration of DHAS, dehydroepiandrosterone (DHA), testosterone (T), estradiol (E2) and progesterone (Prog) were determined by radioimmunoassay. Serum levels of DHAS increased dose-dependently, and were reduced biphasically to normal levels at 24 hr after the administration. Similarly, the levels of DHA, T and E2 increased, and reached the maximum at 30 min after, though the increase of DHA or T was one-thousandth that of DHAS, and that of E2 was about one-hundred-thousandth. On the other hand, Prog concentration in sera decreased to 50 ?? 60% of that before the injection at 30 min after (p<0.05). These results suggest that the changes observed in E2 and Prog levels after the injection of DHAS into pregnant rabbits corresponded to the changes of endogeneous E2 and Prog seen in early parturition in women.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 77 (2), 187-194, 1981

    公益社団法人 日本薬理学会

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