マウスにおけるノイロトロピンの鎮痛効果とＳＡＲＴストレスマウスにおける薬物の鎮痛作用

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タイトル別名
  • Analgesic effects of Neurotropin in mice, and comparison between analgesic effects of some drugs in SART-stress mice and normal mice
  • マウス ニ オケル ノイロトロピン ノ チンツウ コウカ ト SART ストレ

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Analgesic effects of a neuroleptica “Neurotropin” (NSP) were studied in mice while the analgesic effects of other agents were studied in SART-stress mice (specific stress caused by alterating rhythm in temperature) and the results compared with those in normal mice. NSP is an extract containing many conjugated polysaccarides isolated from the skin or tissues of rabbits which had been inoculated with the living cowpox virus. (a) NSP given alone to normal mice resulted in slight analgesic effects as observed with the application of the acetic acid-, phenylquinon-writhing method or the modified Randall-Selitto method. Little effect was seen when the D'Amour-Smith method was used. (b) Synergism was evident when NSP and aminopyrine or NSP and morphine were given concomitantly and the acetic acid or phenylquinon-writhing methods were applied. (c) Analgesic effects of morphine, levomepromazine, imidazole acetic acid and particularly NSP were greater in SART-stress mice than in normal mice. With the D'Amour-Smith method, only NSP had a greater effect in SART-stress mice than in normal mice.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (5), 573-584, 1976

    公益社団法人 日本薬理学会

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