Intercommunication Between cytokine- and Neurotransmitter-Systems. Neuronal cyiokine involvement in synaptic plasticity.
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- TAKAGI Hiroshi
- Department of Neuro-plasticity, Research Center for Aging and Adaptation, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- サイトカインと神経伝達物質 サイトカインと記憶
- サイトカイン ト キオク
- サイトカインと神経伝達物質
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Abstract
Hippocampal long-term potentiation (LTP) is one of the best-studied models of learning and memory at the molecular level. In the hippocampal CA1 region, at least three different LTPs were reported: early phase LTP (E-LTP), late phase LTP (L-LTP) and anoxic LTP (A-LTP). E-LTP is induced by the activation of postsynaptically silent synapses. Unlike the E-LTP, L-LTP is dependent on protein synthesis and may be due to an increase in the number of sites of synapse. Unlike the E- and L-LTP, A-LTP is induced by presynaptic K+ channel modulations and is a crucial trigger for neuronal cell death. Interleukin-1β (IL-1β), which is produced under the anoxic conditions, plays an important role in A-LTP induction, and brain-derived neurotrophic factor (BDNF) plays a crucial role in L-LTP induction. IL-1β antagonist and, or BDNF improve the cerebral anoxia-induced inhibition of E-LTP. These results suggested that the new synaptic sites, products of the BDNF induced L-LTP, will play an important role in synaptic plasticity (ex. E-LTP) instead of the synaptic sites of death neurons (induced by A-LTP). The neuronal cytokine system regulates these LTP expressions co-operatively and may play a crucial role to keep the brain system in the steady-state condition.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 115 (4), 201-207, 2000
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679250392704
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- NII Article ID
- 10005705946
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DC%2BD3cXitlejtb8%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 5325683
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- PubMed
- 10876804
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed