Pharmacological studies of Reiousan which contains bezoar and ginseng: III. Effects on experimental cerebral ischemia.
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- MORISHITA Shin-ichi
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- SHOJI Masamichi
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- OGUNI Yasuhiro
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- SUGIMOTO Chishio
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- HIRAI Yasuharu
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- TOMA Shouji
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
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- ITO Chihiro
- Research Laboratories, Kyushin Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- 牛黄,人参製剤霊黄参の薬理作用 第3報 実験的脳虚血障害に対する作用
- ゴオウ ニンジン セイザイ レイオウサン ノ ヤクリ サヨウ 3 ジッケンテキ
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Abstract
Pharmacological effects of Reiousan, a crude drug preparation consisting of bezoar and ginseng, on experimental cerebral ischemia and anoxia were studied. After administration of Reiousan, the survival time of mice subjected to hypobaric hypoxia and the gasping duration of isolated rat head tended to increase. Reiousan inhibited all the following: lipid peroxides production in rat brain homogenate, tissue swelling induced by the xanthine-xanthine oxidase system in rat brain cortical slices, rat brain swelling induced by freezing, lipid peroxides production in the rat brain after ligation of bilateral common carotid arteries, and lipid peroxides production in Mongolian gerbil brain after reperfusion following ligation of bilateral common carotid arteries. These effects may result from antioxidant activity of bilirubin, a constituent of bezoar.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 98 (6), 435-442, 1991
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679250404608
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- NII Article ID
- 130000758816
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3750363
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- PubMed
- 1783324
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed