書誌事項
- タイトル別名
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- Influence of hexobendine, prenylamine and verapamil on the contractile response of isolated rabbit left atria and aortae to calcium.
- テキシュツ ウサギ シンボウ オヨビ ダイドウミャクジョウヘン カルシウム シュウシュク ニ タイスル Hexobendine,Prenylamine ナラビニ Verapamil ノ エイキョウ
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In isolated rabbit left atria driven electrically at a frequency of 30/min, the contraction was abolished by increasing external K+ concentrations from 5.4 to 22 mM. Addition of isoproterenol (10-6M) restored the atrial contraction and the magnitude of contractions increased by raising external concentrations of Ca++ to 4.4 and 6.6. mM. Hexobendine attenuated the magnitude of contractions restored by isoproterenol and excess Ca++ in a dose-dependent manner, as did prenylamine and verapamil. Hexobendine did not significantly influence the membrane depolarization induced by excess K+ and there was no evidence of a beta-adrenergic blocking action. In helical strips of rabbit aortae exposed to Ca++ -free media and depolarized by excess K+, the addition of Ca++ caused a marked contraction. Hexobendine, prenylamine and verapamil caused a dose-related attenuation of the Ca++-induced contraction. Relative potencies of the inhibition by hexobendine, prenylamine and verapamil were 1:16.5:100. Inhibitory effects of these drugs were partially antagonized by excess Ca++. Greater attenuation of the contractile response to 25 mM K+ than the response to 2 × 10-6M noradrenaline was observed in preparations treated with hexobendine. It may be concluded that interference with the influx of Ca++ across cell membrane in atrial muscles and aortic smooth muscles participates in the inhibition of contractility by hexobendine.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 73 (8), 931-938, 1977
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679250488192
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- NII論文ID
- 130000758850
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaE1cXlsVShs78%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 1916282
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- PubMed
- 611068
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可