Immunological action of Neurotropin. (5). Effect of Neurotropin on immuno-suppression caused by stress.

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  • MATSUOKA Takao
    Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Company
  • YOSHII Haruo
    Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Company
  • SUEHIRO Seishi
    Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Company

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Other Title
  • Ｎｅｕｒｏｔｒｏｐｉｎの免疫薬理学的作用　（第５報）　　ストレス負荷による免疫機能の低下に対する作用
  • Neurotropin ノ メンエキ ヤクリガクテキ サヨウ 5 ストレス フ
  • Effect of Neurotropin on immunosuppression caused by stress
  • ―ストレス負荷による免疫機能の低下に対する作用―

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Neurotropin is an extract isolated from the inflamed skins of rabbits inoculated with Vaccinia virus. A study was carried out to examine the effect of Neurotropin on the immunosuppressions caused by stress. Mice were restrained for 16 hr per day for 2 consecutive days. Under this condition, the immune responses such as PFC and DTH to SRBC, T cell-dependent antigen, were markedly suppressed. Moreover, the phagocytic activity of macrophages were also suppressed. Neurotropin was found to restore such suppressions of both T cell response and phagocytosis in stressed mice. These results suggest that the effect of Neurotropin on depressed immunity in stressed mice were not only restoration of T cell function but also phagocytic activity of macrophages. Neurotropin had no effect on intact immune responses without stress. This suggests that Neurotropin can he used as an effective immunomodulator.

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