メゾ蓚酸鹽の膵臓Insulin含有量に及ぼす影響

DOI

書誌事項

タイトル別名
  • The effect of calcium mesoxalate on the insulin content of the pancreas
公開日
1955
DOI
  • 10.1254/fpj.51.6_676
公開者
公益社団法人 日本薬理学会

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説明

The insulin content of the pancreas was determined in dogs and rats which were administered calcium mesoxalate continuously for a prolonged period. 1) The insulin content of the pancreas increased in rats given daily oral doses of 100 mg/kg for 1, 3, 6 and 12 months. The effect of the drug reached the maximum level after 3 months. 2) The pups, 3-6 kg body weight, were.given daily oral doses of 10 mg/kg and 50 mg/kg for 2 and 6 months. After 2 months the insulin content of the pancreas increased to nearly twice the normal value, but after 6 months there was no significant deviation from the normal pattern. Variance by sex was negligible. 3) The male dogs, 10-15 kg body weight, were given daily doses of 50 mg/kg and 200 mg/kg for 1 and 2 months. The maximum effect occurred in the group of dogs administered doses of 200 mg/kg for 1 month, the insulin content rising to two and half times the normal value. But there was no significant deviation from the normal pattern in the group of dogs administered doses of 50 mg/kg for 2 months.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 51 (6), 676-681,en38, 1955

    公益社団法人 日本薬理学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679251340416
  • NII論文ID
    130001508373
  • DOI
    10.1254/fpj.51.6_676
  • ISSN
    13478397
    00155691
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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