Pharmacological studies on syrosingopine

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  • ONO Nobufumi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • MAEDA Yukihide
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • KAWASAKI Hiromu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • KURODA Masahiro
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • KUSHIKU Kazushi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • FURUKAWA Tatsuo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • KURODA Kiyoshi
    東洋醸造,研究部薬理研究室
  • KIKUCHI Kenjiro
    東洋醸造,研究部薬理研究室
  • SHIMIZU Takeshi
    東洋醸造,研究部薬理研究室

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Other Title
  • Syrosingopine (O-Carbethoxysyringoyl methylreserpate) の中枢,その他に対する作用
  • Syrosingopin O-carbethoxysyringoyl methylreserpate ノ チュウスウ , ソノタ ニ タイスル サヨウ

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Abstract

The effects on the central nervous system as well as other actions of syrosingopine were studied and compared with those of reserpine and rescinnamine. These rauwolfia alkaloids exhibited inhibitory effects on gross behavior, locomotor activities and conditioned avoidance response, and elicited cataleptic, muscle relaxant and gastric ulcerating effects. The alkaloids revealed a drowsy pattern in the spontaneous EEG activity and depressed the EEG arousal response. In those central actions, reserpine was the best, rescinnamine next and syrosingopine least, in that diminishing order of potency. Syrosingopine prolonged the hypnotic effect of thiopental sodium and this action was weaker than that of reserpine. Reserpine inhibited the analgesic effect of morphine, while syrosingopine did not. Syrosingopine excited slightly the movement of intestine but did not influence movement of the uterus. The stellate ganglionic transmission was slightly inhibited but the electrocardiogram was not influenced by syrosingopine. These alkaloids had similar potency in the depressor and negative chronotropic effect, although they showed a different potency in their central actions.

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