Biological Effects of Man-Made Mineral Fibers (I). Reactive Oxygen Species Production and Calcium Homeostasis in Alveolar Macrophages.
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- WANG Qi-en
- Department of Occupational Health, Beijing Medical University
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- HAN Chun-hua
- Division of Postgraduate Student, Beijing Teacher's College of Physical Education
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- WU Wei-dong
- Department of Occupational Health, Beijing Medical University
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- WANG Hong-bing
- Department of Occupational Health, Beijing Medical University
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- LIU Shi-jie
- Department of Occupational Health, Beijing Medical University
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- KOHYAMA Norihiko
- National Institute of Industrial Health, Ministry of Labour
書誌事項
- タイトル別名
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- Reactive Oxygen Species Production and Calcium Homeostasis in Alveolar Macrophages
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説明
10 types of standard mineral fiber samples (JFM fibers) were tested for their cytotoxicity in alveolar macrophages (AM) in vitro experiments, in which UICC chrysotile B was used as a positive control. The cytotoxicity included the production of superoxide anion radical and hydrogen peroxide, depletion of glutathione (GSH) and increase of intracellular free calcium. The results showed that chrysotile and most of the 10 mineral fibers could increase the production of superoxide anion and hydrogen peroxide, deplete the concentration of GSH and increase the level of free intracellular Ca2+ in AM. But all the effects of JFM fibers were lower than that induced by UICC chrysotile B. Although the cytotoxicity of JFM fibers were lower than that of asbestos, these mineral fibers should be used with highly care for workers in industries.
収録刊行物
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- Industrial health
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Industrial health 37 (1), 62-67, 1999
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所