Relationships between Chemical Structures and Mutagenicity: A Preliminary Survey for a Database of Mutagenicity Test Results of New Work Place Chemicals.
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- SAWATARI Katsuhiko
- National Institute of Industrial Health
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- NAKANISHI Yoshifumi
- National Institute of Industrial Health
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- MATSUSHIMA Taijiro
- Japan Bioassey Research Center
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抄録
A database of mutagenicity test results of new chemicals has been developed. Based on the amendment of the Industrial Safety and Health Law (ISHL) in 1979, manufacturers and importers in Japan are required to register any new work place chemicals with bacterial mutagenicity test results. At present more than ten thousand substances have been examined. We have surveyed correlations between 44 substructures and mutagenicity in 2, 857 ISHL data as well as in 1, 207 National Toxicology Program data as a preliminary analysis. The percentages of the mutagenic compounds were calculated. High percentages were found for electrophilic reagents such as epoxides(63%), aromatic nitro compounds(49%) and primary alkyl monohalides(46%). 71% of peroxides was found to be mutagenic. The results suggest that several types of reactions such as nucleophilic substitution reaction, nitrenium cation reaction and radical reaction are included in the process of the mutagenic alterations of DNA.
収録刊行物
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- Industrial health
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Industrial health 39 (4), 341-345, 2001
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390282679256686208
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- NII論文ID
- 130003551016
- 40005265756
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- NII書誌ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 5996812
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- PubMed
- 11758998
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可