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- AOKI Noriaki
- Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine
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- SOMA Kazui
- Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine
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- KATAGIRI Hiroshi
- Department of Public Health, Kitasato University School of Medicine
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- AIZAWA Yoshiharu
- Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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- KADOWAKI Takehiro
- Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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- OHWADA Takashi
- Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine
Bibliographic Information
- Other Title
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- Pulmonary Hemodynamic Effects of 1 1 1
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Abstract
We examined the hemodynamic effects of 1, 1, 1-trichioroethane (TCE) inhalation in anesthetized dogs in acute inhalation experiments. Six adult mongrel dogs with spontaneous respiration were intubated, connected to a one-way valve. TCE was delivered by the tubular system connected to a 30-liter tedlar bag reservoir filled with 1v/v% of TCE. After TCE inhalation, the animals revealed a significant decrease in systemic arterial pressure following a decrease in systemic vascular resistance. Pulmonary arterial pressure, pulmonary vascular resistance and right cardiac work increased significantly. These changes were compatible with clinical manifestations of TCE intoxication in human beings. In conclusion, inhalation of TCE may not only decrease peripheral vascular resistance, but also induce transient disturbance of pulmonary blood flow with subsequent pressure overloading in the right ventricle.
Journal
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- Industrial Health
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Industrial Health 35 (4), 451-455, 1997
National Institute of Occupational Safety and Health
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Keywords
Details 詳細情報について
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- CRID
- 1390282679256724864
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- NII Article ID
- 130003550813
- 110000016722
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- NII Book ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL BIB ID
- 4405856
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- PubMed
- 9348715
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed