Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice
-
- WANG Rui-Sheng
- National Institute of Occupational Safety and Health
-
- OHTANI Katsumi
- National Institute of Occupational Safety and Health
-
- SUDA Megumi
- National Institute of Occupational Safety and Health
-
- KITAGAWA Kyoko
- Department of Biochemistry, Hamamatsu Medical University
-
- NAKAYAMA Keiichi
- Medical Institute of Bioregulation, Kyushu University
-
- KAWAMOTO Toshihiro
- Department of Environmental Health, University of Occupational and Environmental Health
-
- NAKAJIMA Tamie
- Department of Occupational and Environmental Health, Nagoya University
この論文をさがす
抄録
Ethylene glycol monoethyl ether (EGEE) can cause damage to testes and sperm, and its metabolites are believed to play an important role in its toxicity. Aldehyde dehydrogenase 2 (ALDH2) is involved in the metabolism of this chemical. To investigate whether and how the enzyme affects the toxicity of EGEE, we conducted experiments comparing Aldh2 knockout mice with wild-type mice. Administration of EGEE at 100 and 600 mg/kg/day for one week did not induce any significant change in the weight and body weight ratios of testes, prostate and epididymides in either Aldh2 knockout or wild-type mice. However, motion of sperm from the spermaduct, as analyzed with a Hamilton-Thorne Sperm analyzer, was slightly decreased in the low dose group, and significantly lower in the high dose group; and the percentage of progressive sperm was also reduced in the two EGEE groups. This effect of EGEE treatment was observed in the wild-type, but not in the Aldh2 knockout mice. Sperm motion from the cauda epididymides was not affected. On the other hand, the concentration of ethoxyacetic acid, a metabolite of EGEE, in 24 h pooled urine of EGEE-treated Aldh2 knockout mice was not significantly lower than that of the wild-type mice on most days of urine sampling. These results suggest that inactivation of the ALDH2 enzyme due to gene mutation may be linked to differences in the susceptibility to EGEE-induced sperm toxicity. <br>
収録刊行物
-
- Industrial health
-
Industrial health 45 (4), 574-578, 2007
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679256741632
-
- NII論文ID
- 130004828493
-
- NII書誌ID
- AA00672955
-
- ISSN
- 18808026
- 00198366
-
- NDL書誌ID
- 8913879
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可