Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds
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- KIM Jin Hee
- Department of Preventive Medicine, Seoul National University College of Medicine Institute of Environmental Medicine, Seoul National University Medical Research Center
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- MOON Jae Yong
- Department of Preventive Medicine, Seoul National University College of Medicine
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- PARK Eun-Young
- Department of Preventive Medicine, Seoul National University College of Medicine
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- LEE Kwan-Hee
- Department of Occupational & Environmental Medicine, Inha University Hospital
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- HONG Yun-Chul
- Department of Preventive Medicine, Seoul National University College of Medicine Institute of Environmental Medicine, Seoul National University Medical Research Center
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Exposure to volatile organic compounds (VOCs) was known to result in immunologic, respiratory, carcinogenic, reproductive, neurologic, and cardiovascular effects. However, the mechanisms by which VOCs induce these adverse health effects are not well understood. To evaluate the change of oxidative stress biomarker and gene expression levels in workers exposed to VOCs, we obtained urine and blood samples from 21 subjects before and after occupational exposure to VOCs. We measured levels of muconic acid (MuA), hippuric acid (HA), mandelic acid (MaA), and methyl hippuric acid (MHA) as urinary exposure biomarkers for benzene, toluene, ethylbenzene, and xylene (collectively BTEX), and malondialdehyde (MDA) and 8-hydroxydeoxyguanine (8-OHdG) as oxidative stress biomarkers in all subjects. We also evaluated BTEX-mediated RNA expression using cDNA microarray in 14 subjects. HA and MHA levels were higher following occupational exposure to VOCs (p<0.01). In the linear regression analysis, HA ratios of after- and before-exposure were found to be significantly associated with increase of MDA ratios of after- and before-exposure after controlling for age, body mass index, and smoking (β=0.06, p=0.031). Evaluation of the gene expressions by HA showed that 23 gene expressions were found to be significantly associated with HA levels after adjusting for age, body mass index, and smoking (p<0.001). In particular, expressions of ENO3 and CDNA FLJ39461 fis among the 23 genes were significantly associated with the change in MDA level (p<0.05). Our study results suggest that exposure to VOCs, specifically toluene, induces oxidative stress and various gene expression change of which some may be responsible for oxidative stress.<br>
収録刊行物
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- Industrial health
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Industrial health 49 (1), 8-14, 2011
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390282679256792832
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- NII論文ID
- 130004828597
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- NII書誌ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 10972100
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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