Causal Relationship between a Case of Severe Hepatic Dysfunction and Low Exposure Concentrations of N,N-dimethylformamide in the Synthetics Industry.
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- NOMIYAMA Tetsuo
- Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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- UEHARA Masahiro
- The Association of Industrial Health
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- MIYAUCHI Hiroyuki
- The Association of Industrial Health
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- IMAMIYA Shun'ichiro
- The Association of Industrial Health
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- TANAKA Shigeru
- School of Allied Health Science, Faculty of Hygienic Technology, Kitasato University
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- SEKI Yukio
- School of Allied Health Science, Faculty of Hygienic Technology, Kitasato University
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A 19-year-old man suffered hepatic dysfunction after 5 months of exposure to N, Ndimethylformamide (DMF) at his job in the synthetic resins industry. Laboratory data revealed elevated levels of AST (578 IU/l), ALT (1193 IU/l), and γ-GTP (107 IU/l), no viral infection with HAV, HBV, or HCV, and no history or evidence of hepatic injury, although he did have a slight abdominal abnormality and swelling which was detected by palpation. His urinary N-methylformamide level, as a biological exposure index of DMF, was 42.8 mg/l, indicating 10-30 ppm of DMF exposure. After 2 months he was reinstated in two workplaces, the former where he worked in the morning and the other in the afternoon where environmental DMF concentrations were less than those in the former workplace. On the 18th day after his reinstatement, his liver function became exasperated again. After the second period of medication and one month of rest from work, he had fully recovered and was reinstated, but to a workshop without DMF exposure.
収録刊行物
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- Industrial health
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Industrial health 39 (1), 33-36, 2001
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390282679257735168
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- NII論文ID
- 130003550977
- 30035022311
- 40005265715
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- NII書誌ID
- AA00672955
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- COI
- 1:CAS:528:DC%2BD3MXhtlyit78%3D
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 5995168
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- PubMed
- 11212289
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可