Analysis of Bronchoalveolar Lavage Fluid Adhering to Lung Surfactant -Experiment on Intratracheal Instillation of Nickel Oxide with Different Diameters-

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  • KADOYA Chikara
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • OGAMI Akira
    Department of Work Systems and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • MORIMOTO Yasuo
    Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • MYOJO Toshihiko
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • OYABU Takako
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • NISHI Kenichiro
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • YAMAMOTO Makoto
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • TODOROKI Motoi
    Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • TANAKA Isamu
    Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

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Other Title
  • Analysis of Bronchoalveolar Lavage Fluid Adhering to Lung Surfactant
  • Analysis of bronchoalveolar lavage fluid adhering to lung surfactant —Experiment on intratracheal instillation of nickel oxide with different diameters—
  • —Experiment on Intratracheal Instillation of Nickel Oxide with Different Diameters—

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Description

Nickel oxide with two different particle sizes, micron size (NiO) and submicron size (nNiOm), as well as crystalline silica as a positive control and titanium dioxide as a negative control, were intratracheally instilled in rats and the phospholipid concentration and the protein concentration and surface tension of bronchoalveolar lavage fluid (BALF), which are used in surfactant assessment, were measured to see if they could be effective biomarkers in toxicity assessment. The results showed that the NiO instilled group showed no significant difference compared to the control group throughout the observation period. In contrast, a significant difference was found in the nNiOm instilled group compared to the control group throughout the observation period. Moreover, a significant difference was found in the crystalline silica instilled group for each measurement compared to the control group while for the titanium dioxide group, almost no significant difference was found. These results indicate that submicronsized particles of nickel oxide with smaller median diameters potentially have a stronger biological effect than micron size particles. They also indicate that screening can be done by measuring the phospholipid concentration and the protein concentration and surface tension of BALF. <br>

Journal

  • Industrial Health

    Industrial Health 50 (1), 31-36, 2012

    National Institute of Occupational Safety and Health

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