The Mechanism of Maitotoxin-Induced Elevation of the Cytosolic Free Calcium Level in Rat Cerebrocortical Synaptosomes.

DOI Web Site Web Site Web Site PubMed 28 References
  • Satoh Eiki
    Department of Pharmacology, University of Obihiro School of Veterinary Medicine
  • Ishii Toshiaki
    Department of Pharmacology, University of Obihiro School of Veterinary Medicine
  • Nishimura Masakazu
    Department of Pharmacology, University of Obihiro School of Veterinary Medicine

Bibliographic Information

Other Title
  • Mechanism of Maitotoxin Induced Elevation of the Cytosolic Free Calcium Level in Rat Cerebrocortical Synaptosomes

Search this article

Description

The present study was conducted to elucidate the mechanism of the maitotoxin (MTX)-induced increase in intrasynaptosomal free calcium level ([Ca2+]i). The MTX (1 ng/ml)-induced increase in [Ca2+]i was partially inhibited by the omission of extracellular Ca2+ (Ca2+e) or the addition of verapamil, but not by adding nifedipine, ω-agatoxin IVA, ω-conotoxin GVIA and ω-conotoxin MVIIC. An increase in [Ca2+]i in the absence of Ca2+e was sensitive to procaine, TMB-8, genistein and verapamil, but not to ryanodine and U-73122. These results may suggest that MTX increases [Ca2+]i by stimulating Ca2+ entry through voltage-independent nonselective cation channels and Ca2+ release from stores through a phospholipase C-γ1-mediated pathway in rat cerebrocortical synaptosomes.

Journal

References(28)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top