The Mechanism of Maitotoxin-Induced Elevation of the Cytosolic Free Calcium Level in Rat Cerebrocortical Synaptosomes.
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- Satoh Eiki
- Department of Pharmacology, University of Obihiro School of Veterinary Medicine
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- Ishii Toshiaki
- Department of Pharmacology, University of Obihiro School of Veterinary Medicine
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- Nishimura Masakazu
- Department of Pharmacology, University of Obihiro School of Veterinary Medicine
書誌事項
- タイトル別名
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- Mechanism of Maitotoxin Induced Elevation of the Cytosolic Free Calcium Level in Rat Cerebrocortical Synaptosomes
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説明
The present study was conducted to elucidate the mechanism of the maitotoxin (MTX)-induced increase in intrasynaptosomal free calcium level ([Ca2+]i). The MTX (1 ng/ml)-induced increase in [Ca2+]i was partially inhibited by the omission of extracellular Ca2+ (Ca2+e) or the addition of verapamil, but not by adding nifedipine, ω-agatoxin IVA, ω-conotoxin GVIA and ω-conotoxin MVIIC. An increase in [Ca2+]i in the absence of Ca2+e was sensitive to procaine, TMB-8, genistein and verapamil, but not to ryanodine and U-73122. These results may suggest that MTX increases [Ca2+]i by stimulating Ca2+ entry through voltage-independent nonselective cation channels and Ca2+ release from stores through a phospholipase C-γ1-mediated pathway in rat cerebrocortical synaptosomes.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 85 (1), 98-100, 2001
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261284864
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- NII論文ID
- 10007119648
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXotVOqug%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5645959
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- PubMed
- 11243582
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- Web Site
- http://id.ndl.go.jp/bib/5645959
- https://ndlsearch.ndl.go.jp/books/R000000004-I5645959
- https://api.elsevier.com/content/article/PII:S0021519819304780?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819304780?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2001117802
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
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- PubMed
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