Enkephalinergic Neurons in the Periaqueductal Gray and Morphine Withdrawal.

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献1件 参考文献82件
  • Fukunaga Yuko
    Department of Pharmacology,Wakayama Medical College,811-1 Kimiidera,Wakayama-City,Wakayama 641-0012,Japan
  • Kishioka Shiroh
    Department of Pharmacology,Wakayama Medical College,811-1 Kimiidera,Wakayama-City,Wakayama 641-0012,Japan

この論文をさがす

抄録

The effects of opioid(e.g., morphine)withdrawal on levels on endogenous opioid peptides and their mRNA in the various brain regions have been studied.However, the role of this opioidergic mechanism in the mediation of opioid withdrawal is not fully understood.Preproenkephalin(PPE)mRNA in the caudal periaqueductal gray(cPAG), an important brain region in opioid withdrawal, is increased by both opioid antagonist(naloxone)-precipitated and spontaneous morphine withdrawal, but not by various other stresses in rats, indicating a role of endogeneous enkephalins in the cPAG in morphine withdrawal.In addition, PPE mRNA levels in the cPAG increase in the course of the dissipation of morphine withdrawal, and they are returned to the control levels after disappearance of morphine withdrawal signs.Local administration of an enkephalin analog or peptidase inhibitors into the cPAG suppresses morphine withdrawal signs.These facts suggest that enkephalinergic neurons in the PAG may have a critical role in the recovery phase of morphine withdrawal.Recently, an involvement of transcription factors in morphine withdrawal has been suggested.Thus, the possible role of transcription factors in the regulation of PPE gene expression in the cPAG during morphine withdrawal is also discussed.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (3), 175-180, 2000

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

参考文献 (82)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ