Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats.
-
- Miura Katsuyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
-
- Yamanaka Shinya
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
-
- Ebara Tsuneyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
-
- Okumura Michiaki
- Osaka City General Hospital,Osaka 534-0021,Japan
-
- Imanishi Masahito
- Osaka City General Hospital,Osaka 534-0021,Japan
-
- Kim Shokei
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
-
- Nakatani Tatsuya
- Department of Urology,Osaka City University Medical School,Osaka 545-8585,Japan
-
- Iwao Hiroshi
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
この論文をさがす
抄録
The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg-1·min-1, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 82 (3), 261-264, 2000
公益社団法人 日本薬理学会
- Tweet
詳細情報
-
- CRID
- 1390282679261615104
-
- NII論文ID
- 10008183637
-
- NII書誌ID
- AA00691188
-
- COI
- 1:CAS:528:DC%2BD3cXitFOiu7o%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 5321099
-
- PubMed
- 10887957
-
- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5321099
- https://api.elsevier.com/content/article/PII:S0021519819306924?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819306924?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/82/3/82_3_261/_pdf
- https://search.jamas.or.jp/link/ui/2000170655
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可