Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats.
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- Miura Katsuyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Yamanaka Shinya
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Ebara Tsuneyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Okumura Michiaki
- Osaka City General Hospital,Osaka 534-0021,Japan
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- Imanishi Masahito
- Osaka City General Hospital,Osaka 534-0021,Japan
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- Kim Shokei
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Nakatani Tatsuya
- Department of Urology,Osaka City University Medical School,Osaka 545-8585,Japan
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- Iwao Hiroshi
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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Abstract
The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg-1·min-1, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 82 (3), 261-264, 2000
The Japanese Pharmacological Society