Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats.

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  • Miura Katsuyuki
    Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
  • Yamanaka Shinya
    Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
  • Ebara Tsuneyuki
    Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
  • Okumura Michiaki
    Osaka City General Hospital,Osaka 534-0021,Japan
  • Imanishi Masahito
    Osaka City General Hospital,Osaka 534-0021,Japan
  • Kim Shokei
    Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
  • Nakatani Tatsuya
    Department of Urology,Osaka City University Medical School,Osaka 545-8585,Japan
  • Iwao Hiroshi
    Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan

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Abstract

The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg-1·min-1, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.

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