Comparative Study of the Effects of Indomethacin and NS-398, a Selective Cyclooxygenase 2 Inhibitor, on Duodenal Bicarbonate Secretion Induced by Luminal Acidification in Rats.
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- Iwata Kazumi
- Research and Development Laboratories, Maruho Co.
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- Murakami Naofumi
- Research and Development Laboratories, Maruho Co.
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- Takase Hiroshi
- Research and Development Laboratories, Maruho Co.
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- Saito Takako
- Research and Development Laboratories, Maruho Co.
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- Naruse Tomohiro
- Research and Development Laboratories, Maruho Co.
Bibliographic Information
- Other Title
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- Comparative Study of the Effects of Ind
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Abstract
To clarify the mechanisms of duodenal ulcerogenic activity of non-steroidal anti-inflammatory drugs (NSAIDs), the effects of indomethacin (IND) on acid-stimulated duodenal bicarbonate secretion and histamine-induced duodenal ulcerogenic responses were studied in comparison with NS-398, a selective cyclooxygenase (COX)-2 inhibitor, in rats. IND (1 and 5 mg/kg, s.c.) significantly decreased duodenal bicarbonate secretion and potentiated duodenal lesion in a dose-dependent manner. On the other hand, NS-398 had no effect on these parameters. These findings suggest that duodenal ulcerogenicity of IND in the presence of histamine is mainly due to the inhibitory action on acid-stimulated bicarbonate secretion mediated by COX-1, but not by COX-2.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 75 (2), 191-194, 1997
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679261992064
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- NII Article ID
- 10008189742
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXntVKmurk%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4326418
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- PubMed
- 9414035
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed