Pathophysiological Effects of Dietary Essential Fatty Acid Balance on Neural Systems.

Yoshida Satoshi, Sato Akira, Okuyama Harumi

doi:10.1254/jjp.77.11

Pathophysiological Effects of Dietary Essential Fatty Acid Balance on Neural Systems.

DOI Web Site Web Site Web Site Web Site PubMed ほか1件をすべて表示一部だけ表示被引用文献3件参考文献181件オープンアクセス

Yoshida Satoshi

Research Laboratory Center, Oita Medical University
Sato Akira

Faculty of Pharmaceutical Sciences, Nagoya City University
Okuyama Harumi

Faculty of Pharmaceutical Sciences, Nagoya City University

書誌事項

タイトル別名

Pathophysiological Effects of Dietary E

この論文をさがす

説明

Dietary fatty acid balance has been revealed to affect neural functions as well as chronic diseases such as cancer, cerebro- and cardiovascular diseases, and allergic hyper-reactivity. In this review, we focused on the pathophysiological effects of n-6 and n-3 fatty acids on brain functions. Long-term n-3 fatty acid deficiency in the presence of n-6 fatty acids has been shown to affect learning behavior, drug sensitivity and retinal functions. Some membrane enzymes and ion channel functions have been shown in experimental animals to be regulated by membrane fatty acid modifications. We also summarized the effects of these fatty acids in diets on human psychotic aspects and brain diseases. Although biochemical mechanisms remain to be elucidated, investigations on the effect of dietary fatty acids on neural networks may provide an important clue to clarify complex brain functions.