Deterioration of Spatial Learning Performances in Lipopolysaccharide-Treated Mice.

DOI Web Site Web Site Web Site PubMed 被引用文献6件 参考文献41件
  • Arai Ken
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The Universe of Tokyo
  • Matsuki Norio
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The Universe of Tokyo
  • Ikegaya Yuji
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The Universe of Tokyo
  • Nishiyama Nobuyoshi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The Universe of Tokyo

この論文をさがす

抄録

It is well demonstrated that acute or chronic stress leads to reduction of learning ability. Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, induces profound physiological and behavioral changes, including fever, decrease in food motivation, and decrease in social behavior. These changes might be interpreted as an acute stress reaction to the LPS. In the present study, therefore, we investigated the effects of LPS (400 – 800 μg/kg, i.p.) on spatial learning performances using C57BL/6J male mice. In the Morris water-maze task, spatial learning performances were examined in six trials of training for two consecutive days. LPS-treated mice took a longer time to reach the hidden platform than control mice (F(1,60) = 4.80801, P<0.05 at 600 μg/kg). In addition, injection of LPS decreased the percent of correct choices in the Y-maze test (P<0.05 at 800 μg/kg). LPS, however, did not alter the body weight, grip tone, motor activity or swimming speed. Taken together, these results indicate that LPS treatment specifically impaired spatial learning performances.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 87 (3), 195-201, 2001

    公益社団法人 日本薬理学会

被引用文献 (6)*注記

もっと見る

参考文献 (41)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ