A Comparative Study of the Fluoroquinolone Antibacterial Agents on the Action Potential Duration in Guinea Pig Ventricular Myocardia.
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- Hagiwara Takehiro
- New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
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- Satoh Sumie
- New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
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- Kasai Yoshio
- New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
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- Takasuna Kiyoshi
- New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- Comparative Study of the Fluoroquinolone Antibacterial Agents on the Action Potential Duration in Guinea Pig Ventricular Myocardia
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抄録
We examined the effects of ten fluoroquinolone antibacterial agents, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin, tosufloxacin, gatifloxacin, grepafloxacin, moxifloxacin and sparfloxacin, on action potentials recorded from guinea pig ventricular myocardia. Sparfloxacin prolonged action potential duration (APD) by about 8% at 10 μM and 41% at 100 μM. Gatifloxacin, grepafloxacin and moxifloxacin also prolonged APD at 100 μM by about 13%, 24% and 25%, respectively. In contrast, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin and tosufloxacin had little or no APD-prolonging effect at concentrations as high as 100 μM. These findings suggest that there are differences in potency to prolong QT interval among the fluoroquinolones.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 87 (3), 231-234, 2001
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679262088192
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- NII論文ID
- 10007368521
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXovVylsbo%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5984901
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- PubMed
- 11885973
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可