Potentiation of EPN-induced Inhibition of Liver Microsomal Carboxylesterase by Addition of Liver Cytosol from 6-Aminonicotinam de-Treated, Starved Rats
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- SUGIYAMA Seiyu
- Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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- SATOH Tetsuo
- Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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- UENO Koichi
- Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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- IGARASHI Takashi
- Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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- KITAGAWA Haruo
- Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
書誌事項
- タイトル別名
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- Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats.
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説明
Addition of liver cytosol from 16 hr-starved rats treated with 6-aminonicotinamide to rat liver microsomes caused potentiation of the anti-carboxylesterase action of ethyl-p-nitrophenyl phenylphosphonothioate (EPN). This was not found when liver cytosol from non-pretreated rats after 16 hr-starvation was used. This potentiation of EPN-induced inhibition of carboxylesterase may be, at least in part, explained by the fact that treatment of rats with 6-aminonicotinamide resulted in a significant increase in NADPH level in liver cytosol which, in turn, stimulated formation of an EPN oxygen analog, a potent inhibitor of carboxylesterase, through cytochrome P-450-coupled monooxygenase.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 35 (4), 433-437, 1984
公益社団法人 日本薬理学会
