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Adrenomedullin Inhibits the Pressor Effects and Decrease in Renal Blood Flow Induced by Norepinephrine or Angiotensin II in Anesthetized Rats.
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- Minami Kouichiro
- Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine
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- Segawa Kayoko
- Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
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- Uezono Yasuhito
- Department of Pharmacology, Miyazaki Medical College, School of Medicine
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- Shiga Yosuke
- Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine
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- Shiraishi Munehiro
- Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine
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- Ogata Junichi
- Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine
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- Shigematsu Akio
- Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine
Bibliographic Information
- Other Title
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- Adrenomedullin Inhibits the Pressor Effects and Decrease in Renal Blood Flow Induced by Norepinephrine or Angiotensin 2 in Anesthetized Rats
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Description
Adrenomedullin (AM), a hypotensive peptide originally isolated from human pheochromocytoma, has been reported to regulate renal functions. In patients with glomerulonephritis, the serum levels of AM are elevated as well as hypertensive agents norepinephrine (NE) and angiotensin II (AII). The effects of AM on the NE- or AII-induced pressor effects and renal blood flow responses, however, are not well clarified. We examined the effects of AM on blood pressure and renal blood flow induced by NE or AII in anesthetized rats. Arterial blood pressure and renal blood flow were measured using a calibrated pressure transducer and a laser Doppler flowmeter, respectively. Drugs were injected into the tail vein with a syringe. Intravenous administration of AM (1 - 3 nmol/kg) decreased the arterial blood pressure in anesthetized rats in a dose-dependent manner, whereas it did not affect the renal blood flow. NE or AII administration in anesthetized rats caused both increases in blood pressure and decreases in renal blood flow. Simultaneous administration of AM with NE or AII prevented the increasing effects of blood pressure and inhibited the decreases in renal blood flow caused by NE or AII. These findings suggest that AM may have a protective role against the pressor effects and decrease in renal blood flow caused by NE or AII.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 86 (2), 159-164, 2001
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679262367744
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- NII Article ID
- 10007122079
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXksleiu7g%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 5817350
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- PubMed
- 11459117
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- Web Site
- http://id.ndl.go.jp/bib/5817350
- https://ndlsearch.ndl.go.jp/books/R000000004-I5817350
- https://api.elsevier.com/content/article/PII:S0021519819303622?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819303622?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2001265091
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed