A Novel Na+ and Ca〔2+〕Channel Blocker,T-477,Prevents Brain Edema Following Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
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- Okuyama Kayoko
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Kiuchi Satoko
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Okamoto Masahito
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Narita Hiroshi
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Kudo Yukitsuka
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
書誌事項
- タイトル別名
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- A Novel Na+ and Ca2+ Channel Blocker, T-477, Prevents Brain Edema Following Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats.
- Novel Na and Ca 2 Channel Blocker T-477 Prevents Brain Edema Following Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
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抄録
One of the most common acute complications of stroke is brain edema. Treatment of edema is recommended when the condition of the patients is deteriorating. The present study was undertaken to evaluate the effect of T-477 [(R)-(+)-2-(4-chlorophenyl)-2, 3-dihydro-4-diethyl aminoacetyl-4H-1, 4-benzothiazine hydrochloride], a novel neuronal Na+ and Ca2+ channel blocker, on brain edema in rats. Cerebral ischemia was induced by intra-arterial infusion of 1000 microspheres into the forebrain of freely moving rats, resulting in brain edema. T-477 was intravenously infused continuously for 24 h or twice for 3 h with a 3-h interval between infusions immediately after microsphere injection. T-477 dose-dependently inhibited the increase in brain water content by both infusion procedures; the inhibition was statistically significant at doses of 25 mg/kg per 24 h and 14 mg/kg per 9 h. Additionally, infusion of T-477 at a dose of 14 mg/kg per 9 h significantly inhibited the decrease in K content and the increase in Ca content of the forebrain. In conclusion, T-477 prevents brain edema following microsphere-induced cerebral embolism in rats.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 81 (2), 170-175, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679262395776
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- NII論文ID
- 10008196782
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXmvFahtLs%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4886646
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- PubMed
- 10591474
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可