Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine (SB-tPS) Reduces Ischemic Damage in the Gerbil Hippocampus.
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- Suzuki Satoru
- Yakult Central Institute for Microbiological Research
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- Furushiro Masayoshi
- Yakult Central Institute for Microbiological Research
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- Takahashi Masatoshi
- Yakult Central Institute for Microbiological Research
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- Sakai Masashi
- Yakult Central Institute for Microbiological Research
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- Kudo Satoshi
- Yakult Central Institute for Microbiological Research
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Description
Mongolian gerbils orally administered with soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS, 240 mg/kg) for 5 days were subjected to cerebral ischemia by bilateral common carotid artery occlusion. The pyramidal cell damage of the hippocampal CA1 subfield was classified into 4 grades according to the proportion of damaged neurons on the tenth day after the ischemic treatment. The damage score of the SB-tPS group was statistically less than that of the control group. This suggests that the pre-administration of SB-tPS may relieve the delayed neuronal cell death caused by cerebral ischemia.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 81 (2), 237-239, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679262413952
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- NII Article ID
- 10008197041
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXmvFahtbo%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4886734
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- PubMed
- 10591483
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
