Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation.
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- Iwahori Yuki
- Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Ikegaya Yuji
- Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Matsuki Norio
- Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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説明
The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (Ih) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of Ih compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated Ih amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate Ih channel activity in caudal and medial NTS neurons.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 88 (4), 459-462, 2002
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679262495872
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- NII論文ID
- 130000078241
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- NII書誌ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD38zgsFGlsw%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 6263477
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- PubMed
- 12046990
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- Web Site
- http://id.ndl.go.jp/bib/6263477
- https://ndlsearch.ndl.go.jp/books/R000000004-I6263477
- https://api.elsevier.com/content/article/PII:S0021519819301702?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819301702?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2002261019
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- 本文言語コード
- en
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- journal article
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