Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation.

Iwahori Yuki, Ikegaya Yuji, Matsuki Norio

doi:10.1254/jjp.88.459

Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation.

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Iwahori Yuki

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Ikegaya Yuji

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Matsuki Norio

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo

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説明

The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (I_h) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of I_h compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated I_h amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT_1A receptor antagonist. Thus, 5-HT_1A receptors may regulate I_h channel activity in caudal and medial NTS neurons.