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Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization.
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- KIYOTA Yoshihiro
- Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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- HAMAJO Kazuhiro
- Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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- MIYAMOTO Masaomi
- Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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- NAGAOKA Akinobu
- Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
Bibliographic Information
- Other Title
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- Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolism
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Description
Effect of idebenone (CV-2619) on memory impairment was studied in rats with cerebral embolization. The cerebral embolization, produced by injecting 2000 microspheres into the internal carotid artery, caused a significant impairment in passive avoidance response. Repeated administrations of idebenone (30 mg/kg/day, i.p.), partially but significantly improved the impairment of the passive avoidance response in the embolized rats. The results suggest that the repeated administration of idebenone exerts an ameliorating effect on memory impairment induced by cerebral embolization.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 37 (3), 300-302, 1985
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679262811136
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- NII Article ID
- 130000834952
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaL2MXhvFOrs7g%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- PubMed
- 3999479
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed