Inhibitory Effect of(4R)-Hexahydro-7,7-Dimethyl-6-Oxo-1,2,5-Dithiazocine-4-Carboxylic Acid(SA3443), a Novel Cyclic disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells.

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  • Sasano Minoru
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
  • Nakata Katsuhiko
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
  • Mita Shiro
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.

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  • Inhibitory Effect of (4R)-Hexahydro-7,7-Dimethyl-6-Oxo-l,2,5-Dithiazocine-4-Carboxylic Acid (SA3443), a Novel Cyclic Disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells

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The effect of (4R)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on tumor necrosis factor (TNF)-like factor production from Propionibacterium acnes (P. acnes)-primed rat liver macrophages/Kupffer cells was investigated. A remarkable increase in TNF-like activity was detected in the culture supernatants of the liver macrophages/Kupffer cells from P. acnes-treated rats. At concentrations of 1 × 10-6 to 1 × 10-4 M, SA3443 significantly inhibited the production/release of TNF-like factor from these P. acnes-primed/activated liver macrophages/Kupffer cells.

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