- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Inhibitory Effect of(4R)-Hexahydro-7,7-Dimethyl-6-Oxo-1,2,5-Dithiazocine-4-Carboxylic Acid(SA3443), a Novel Cyclic disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells.
-
- Sasano Minoru
- Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
-
- Nakata Katsuhiko
- Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
-
- Mita Shiro
- Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
-
- Inhibitory Effect of (4R)-Hexahydro-7,7-Dimethyl-6-Oxo-l,2,5-Dithiazocine-4-Carboxylic Acid (SA3443), a Novel Cyclic Disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells
Search this article
Description
The effect of (4R)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on tumor necrosis factor (TNF)-like factor production from Propionibacterium acnes (P. acnes)-primed rat liver macrophages/Kupffer cells was investigated. A remarkable increase in TNF-like activity was detected in the culture supernatants of the liver macrophages/Kupffer cells from P. acnes-treated rats. At concentrations of 1 × 10-6 to 1 × 10-4 M, SA3443 significantly inhibited the production/release of TNF-like factor from these P. acnes-primed/activated liver macrophages/Kupffer cells.
Journal
-
- The Japanese Journal of Pharmacology
-
The Japanese Journal of Pharmacology 59 (4), 493-496, 1992
The Japanese Pharmacological Society
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679262959360
-
- NII Article ID
- 130000840082
-
- COI
- 1:CAS:528:DyaK38XmtVGitLo%3D
-
- ISSN
- 13473506
- 00215198
-
- PubMed
- 1434146
-
- Text Lang
- en
-
- Article Type
- journal article
-
- Data Source
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed