Possible Involvement of Suppression of Th2 Differentiation in the Anti-allergic Effect of Sho-seiryu-to in Mice.
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- Ikeda Yoshiki
- Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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- Kaneko Atsushi
- Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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- Yamamoto Masahiro
- Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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- Ishige Atsushi
- Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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- Sasaki Hiroshi
- Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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説明
The clinical effectiveness of the Kampo medicine Sho-seiryu-to (SST) has recently been demonstrated in a double-blind randomized study of allergic asthma and rhinitis. We investigated the effect of SST on a type 1 allergic model in mice. Ovalbumin (OVA)-induced sneezing and the total and OVA-specific IgE levels were significantly suppressed with SST at 1.0 g/kg, but that of OVA-specific IgG2a was not. In the splenocytes isolated from SST-administered mice, OVA-induced interleukin (IL)-4 production decreased while interferon (IFN)-γ production was not. The co-culture experiments using purified CD4+T cells and antigen-presenting cells (APCs) suggested that SST influenced both cell types. Flow-cytometric analysis showed that SST suppressed the number of IL-4 producing CD4+T cells but not the number of IFN-γ producing CD4+T cells. The CD86+ major histocompatibility complex class II+ (MHC II)+ cells and CD28+CD4+T cells were decreased by SST treatment, while CD80+MHC II+ cells, CD40+MHC II+ cells and CD154+CD4+T cells showed no change. These data suggested that SST may suppress IL-4 production in CD4+T cells via influencing CD28-CD86 interaction. In addition to the previously reported inhibitory activity on histamine release, suppression of Th2 differentiation at the stage of APC-CD4+T cell interaction may be involved in the anti-allergic effects of SST.<br>
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 90 (4), 328-336, 2002
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679263132800
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- NII論文ID
- 130000078404
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- NII書誌ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD38jjslyqsw%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 6396838
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- PubMed
- 12501009
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- Web Site
- http://id.ndl.go.jp/bib/6396838
- https://ndlsearch.ndl.go.jp/books/R000000004-I6396838
- https://api.elsevier.com/content/article/PII:S0021519819300058?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819300058?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2003148311
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- 本文言語コード
- en
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- JaLC
- NDL
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- PubMed
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