Protective Effect of Ebselen, a Seleno-Organic Compound, Against the Progression of Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats.
-
- Ohta Yoshiji
- Department of Chemistry, School of Medicine, Fujita Health University
-
- Kobayashi Takashi
- Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University
-
- Inui Kazuo
- Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University
-
- Yoshino Junji
- Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University
-
- Nakazawa Saburo
- Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University
この論文をさがす
説明
The protective effect of ebselen, which possesses glutathione peroxidase-like activity and antioxidative and anti-inflammatory properties, against the progression of acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (0.75 mg/kg). Ebselen (50, 100 or 200 mg/kg) was orally administered 0.5 h after compound 48/80 treatment, at which time gastric mucosal lesions appeared. Post-administered ebselen suppressed gastric mucosal lesion progression at 3 h after compound 48/80 treatment dose-dependently, although no dose of ebselen affected the decreased gastric mucosal blood flow and increased serum serotonin and histamine concentrations found at 3 h after the treatment. A decrease in Se-glutathione peroxidase activity and increases in myeloperoxidase and xanthine oxidase activities and the concentration of thiobarbituric acid reactive substances were found in gastric mucosal tissues at 0.5 h after compound 48/80 treatment, and these changes were further enhanced at 3 h. Post-administered ebselen attenuated all these changes found at 3 h after compound 48/80 treatment dose-dependently. The present results indicate that ebselen exerts a protective effect against the progression of compound 48/80-induced acute gastric mucosal lesions in rats, and they suggest that this protective effect of ebselen could be due to its glutathione peroxidase-like activity and its antioxidative and anti-inflammatory properties.<br>
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 90 (4), 295-303, 2002
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679263293824
-
- NII論文ID
- 130000078400
-
- NII書誌ID
- AA00691188
-
- COI
- 1:STN:280:DC%2BD38jjslyrug%3D%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 6396735
-
- PubMed
- 12501005
-
- Web Site
- http://id.ndl.go.jp/bib/6396735
- https://ndlsearch.ndl.go.jp/books/R000000004-I6396735
- https://api.elsevier.com/content/article/PII:S0021519819300010?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819300010?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2003148307
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可