Angiotensin 2-Induced Pulmonary Edema in a Rabbit Model

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  • Yamamoto Takatsugu
    Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
  • Wang Li-man
    Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
  • Shimakura Kazuro
    Department of Surgery, Teikyo University School of Medicine, Mizonokuchi Branch
  • Sanaka Masaki
    Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University First Department of Internal Medicine, Teikyo University School of Medicine
  • Koike Yuichi
    Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
  • Mineshita Satoru
    Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University

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タイトル別名
  • Angiotensin II-Induced Pulmonary Edema in a Rabbit Model.
  • Angiotensin 2 Induced Pulmonary Edema i

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We conducted the present study to propose a rabbit model of pulmonary edema (PE)induced by angiotensin II (All)and to test the preventive effect of losartan on this form of PE. All was administered to rabbits intravenously at 50, 100, 150 or 300 μg/kg, either by continuous infusion (10 min)or by bolus injection (30 sec). Continuously administered All (150 μg/kg)induced PE in most cases, while a bolus injection of the same dosage did not. Additionally, the incidence of PE increased with higher dosages of All when it was infused continuously. A newly established parameter, the area under the systolic blood pressure-time curve corrected by baseline (cAUC), was prone to rise as the incidence of PE increased. Moreover, cAUC signficantly correlated with the wet-dry lung weight ratio (r=0.66, P<0.05). Subsequently, 0.5 or 3.0 mg/kg of losartan was given before continuous infusion of 150 μg/kg of All. The higher dosage of losartan prevented PE completely, while the lower one did so moderately. We concluded that intravenous administration of All induces PE, probably as a result of increasing afterload. Furthermore, an adequate dosage of losartan can prevent PE because it reduces the pressor effect of All.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 73 (1), 33-40, 1997

    公益社団法人 日本薬理学会

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