Inhibitory Effects of Bifemelane on Brain Ca2+Channel Subtypes Expressed in Xenopus Oocytes.
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- Kinoshita Mariko
- Departments of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Kaneko Shuji
- Departments of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Yasuno Tohru
- Departments of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Yada Nobumichi
- Departments of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Akaike Akinori
- Departments of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Satoh Masamichi
- Departments of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
書誌事項
- タイトル別名
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- Inhibitory Effects of Bifemelane on Bra
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Effects of the cerebroprotective agent bifemelane on voltage-dependent Ca2+ channel currents were evaluated in Xenopus oocytes expressing specific Ca2+-channel subtypes. Extracellular perfusion of bifemelane showed a dose-dependent blocking action on both N-type and Q-type Ca2+ channels, but not on cardiac L-type Ca2+ channels expressed in the oocytes, and the inhibitory action on Q-type current was stronger than that on N-type current. The time course of inhibition by bifemelane was comparatively slow; a 20-min perfusion with 1 μM bifemelane was required to reduce the amplitude of the Q-type current to 80% of the control level. When bifemelane was applied intracellularly, the potency and time-course of inhibition was equivalent to that caused by the perfusion of bifemelane. The bifemelane-induced inhibition was voltage-dependent but not use-dependent in Q-type channels since it was apparent at more depolarized potentials but not influenced by the interval of depolarization. These results suggest that bifemelane inhibits the opening of the specific Ca2+ channels located at nerve terminals to suppress excessive neurotransmitter release from neurons in some pathophysiological conditions such as ischemia.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 78 (1), 39-44, 1998
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679263533568
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- NII論文ID
- 10008193673
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXmtlCktbg%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4565701
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- PubMed
- 9804060
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- Web Site
- http://id.ndl.go.jp/bib/4565701
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565701
- https://api.elsevier.com/content/article/PII:S0021519819310662?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310662?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_39/_pdf
- https://search.jamas.or.jp/link/ui/1999000420
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可