Protective Effect of Talipexole on MPTP-Treated Planarian, a Unique Parkinsonian Worm Model.
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- Kitamura Yoshihisa
- Department of Neurobiology, Kyoto Pharmaceutical University
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- Kakimura Jun-ichi
- Department of Neurobiology, Kyoto Pharmaceutical University
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- Taniguchi Takashi
- Department of Neurobiology, Kyoto Pharmaceutical University
Bibliographic Information
- Other Title
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- Protective Effect of Talipexole on MPTP
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Description
The planarian, a flatworm, has a high potential for regeneration, and dopamine plays a key role in its behavior. Planarians treated with MPTP underwent autolysis and individual death in a concentration-dependent manner. When the planarian body was cut into anterior, middle and posterior pieces, each piece subsequently regenerated and reorganized to form a new individual within approximately 10 days. The anterior piece was significantly more sensitive than the middle and posterior pieces to MPTP cytotoxicity. Concomitant treatment with talipexole, an anti-parkinsonian drug, inhibited MPTP-induced autolysis and individual death in a concentration-dependent manner. Pramipexole showed a similar protective effect. In addition, post-treatment with talipexole at 1 hr after MPTP completely inhibited MPTP-induced individual death. Although MPTP treatment caused 30% of the planarians to undergo autolysis and individual death within 12 hr, post-treatment with talipexole even at 12 hr completely rescued the remaining 70% of the planarians from death. These results suggest that the MPTP-treated planarian may be useful as a novel parkinsonian model in which talipexole has a protective effect even in the case of post-treatment.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (1), 23-29, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679263536128
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- NII Article ID
- 10008193601
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXmtlCktbo%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4565699
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- PubMed
- 9804058
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- Web Site
- http://id.ndl.go.jp/bib/4565699
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565699
- https://api.elsevier.com/content/article/PII:S0021519819310649?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310649?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_23/_pdf
- https://search.jamas.or.jp/link/ui/1999001870
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed