Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig.

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  • Katoh Yoko
    Department of Internal Medicine III,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan
  • Hashimoto Shigeatsu
    Department of Internal Medicine III,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan
  • Kimura Junko
    Department of Pharmacology,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan
  • Watanabe Tsuyoshi
    Department of Internal Medicine III,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan

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We investigated the effects of troglitazone, a new orally active hypoglycemic agent, on the voltage-dependent L-type Ca2+ current in single cardiac ventricular myocytes of guinea pigs by the whole-cell voltage clamp technique.Troglitazone blocked the Ca2+ currents in a concentration-dependent manner.The inhibitory effect was more potent at the holding potential(HP)of −50mV than at −80mV.The half-maximum inhibiting concentration(IC50)of troglitazone was 0.8μM with the Hill coefficient of 0.84 at −50mV HP.In contrast, the IC50 value was higher than 10μM at −80mV HP.These results suggest that troglitazone at therapeutic concentrations inhibit the Ca2+ channels and may exert cardioprotective effects in diabetic conditions.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (2), 102-109, 2000

    公益社団法人 日本薬理学会

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