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Effects of calcium antagonists and lidocaine on conduction delay induced by acute myocardial ischemia in dogs.
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- NAKAYA Haruaki
- 2nd Department of Pharmacology, Hokkaido University, School of Medicine
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- HATTORI Yuichi
- 2nd Department of Pharmacology, Hokkaido University, School of Medicine
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- KANNO Morio
- 2nd Department of Pharmacology, Hokkaido University, School of Medicine
Bibliographic Information
- Other Title
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- Effects of Calcium Antagonists and Lido
- Effects of Polyamines on Ethylmorphine N-Demethylation in Rat Liver Microsomes
- Effects of Polyamines on Ethylmorphine
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Description
Effects of calcium antagonists and lidocaine on the conduction delay observed in the ischemic myocardium were studied in 24 open-chest anesthetized dogs. Acute myocardial ischemia was produced by complete occlusion of the left anterior descending coronary artery (LAD) for 5 or 10 minutes. The conduction time was measured from the initial deflection of V waves on the His bundle electrograms to the major deflection of the bipolar electrograms recorded from the ischemic and non-ischemic subepicardium under a constant atrial pacing. LAD occlusion produced conduction delay in the ischemic zone (14.3±2.3 msec, p<0.001) with no effect on the normal zone. This ischemia-induced conduction delay was reversible and rate-dependently increased. Administration of lidocaine (2 mg/kg bolus, 4.3 mg/kg/hr constant infusion) prior to the second occlusion increased conduction delay by 12.9±1.9 msec (p<0.001) whereas diltiazem (0.4 mg/kg i.v.) and verapamil (0.3 mg/kg i.v.) reduced the ischemia-induced conduction delay by 12.7±4.9 msec (p<0.05) and 8.4±1.8 msec (p<0.001), respectively. These results indicate that slow channel blocking agents reduce the conduction delay induced by the myocardial ischemia, in contrast with the prolonging effect of lidocaine.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 30 (5), 587-597, 1980
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679263719936
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- NII Article ID
- 130000835733
- 130000835734
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaL3cXmtFGmsLw%3D
- 1:CAS:528:DyaL3MXhtFeltg%3D%3D
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- ISSN
- 13473506
- 00215198
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- Web Site
- http://id.ndl.go.jp/bib/2225888
- https://ndlsearch.ndl.go.jp/books/R000000004-I2225888
- http://id.ndl.go.jp/bib/2225900
- https://ndlsearch.ndl.go.jp/books/R000000004-I2225900
- https://api.elsevier.com/content/article/PII:S0021519819529614?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819529614?httpAccept=text/plain
- https://api.elsevier.com/content/article/PII:S0021519819529602?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819529602?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1981113934
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed