Pharmacology and Cardiovascular Implications of the Kinin-Kallikrein System.

DOI Web Site Web Site Web Site Web Site View 1 Remaining Hide 544 References
  • Dendorfer Andreas
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Lübeck
  • Wolfrum Sebastian
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Lübeck
  • Dominiak Peter
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Lübeck

Search this article

Description

Kinins are peptide hormones that can exert a significant influence on the regulation of blood pressure and vascular tone due to their vasodilatatory, natriuretic and growth modulating activity. Their cardiovascular involvement in physiological and pathophysiological situations has been studied intensively since inhibitors for angiotensin I-converting enzyme and selective receptor antagonists have become available for pharmacologically potentiating or inhibiting kinin-mediated reactions. Molecular biological analysis and the establishment of genetically modified animal models have also allowed newer information to be acquired on this subject. In this review, the components and cardiovascularly relevant mechanisms of the kinin-kallikrein system shall be described. Organ-specific effects concerning the kidneys, the vascular system, the heart and nervous tissue shall also be illustrated. On this tissue, the physiological functions and pathophysiological implications of the kinin-kallikrein system should be clearly distinguished from the many, mostly endothelium-mediated protective effects which occur during ACE inhibition due to the potentiation of kinin effects. Finally, a view shall also be cast upon newly discovered targets of action, which could be exploited for therapeutically altering the kinin-kallikrein system.

Journal

References(544)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top