Triphenyltin-induced increase in the intracellular Ca2+of dissociated mammalian CNS neuron: Its independent from voltage-dependent Ca2+channels
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- Oyama Yasuo
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
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- Chikahisa Lumi
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
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- Hayashi Akemi
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
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- Ueha Toshiko
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
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- Sato Mitsuhiro
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
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- Matoba Hideki
- Department of Health Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima
書誌事項
- タイトル別名
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- Triphenyltin-Induced Increase in the Intracellular Ca2+ of Dissociated Mammalian CNS Neuron: Its Independence from Voltage-Dependent Ca2+ Channels.
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説明
To test the possibility that triphenyltin (TPT) increases the intracellular Ca2+ ([Ca2+]i) in neurons as found previously in thymocytes, the effect of TPT on [Ca2+]i was examined in rat cerebellar neurons by a flow-cytometer with fluorescent dyes. TPT at concentrations ranging from 3 × 10-7 M to 1 × 10-5 M dose-depend ently increased the [Ca2+]i. The TPT-induced increase in [Ca2+]i was not attenuated by a Ca2+ channel blocker, suggesting that it was not dependent on voltage-dependent Ca2+ channels. As the concentration of external Ca2+ ([Ca2+]e) increased, TPT produced a more profound increase in the [Ca2+]i. However, the increase in the [Ca2+]i by TPT was observed even in nominally [Ca2+]e-free solution. These results suggest two possibilities. First, TPT may promote Ca2+-influx to the neuron. Secondly, TPT may affect the intracellular Ca-store sites. This study is relevant to the neurotoxicity of organotins because it has become progressively clear that sustained increases in the [Ca2+]i can activate various Ca2+-dependent degradative processes.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 58 (4), 467-471, 1992
公益社団法人 日本薬理学会
