Antinociceptive Effect of Vitamin K2 (Menatetrenone) in Diabetic Mice.

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  • Onodera Kenji
    Department of Dental Pharmacology, Okayama University Dental School
  • Zushida Ko
    Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
  • Kamei Junzo
    Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

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Abstract

The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10 - 100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.

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