Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α1B-Receptor Blockade but Not by α1A-Blockade

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  • Yang Xiao-Ping
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
  • Chiba Shigetoshi
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan

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タイトル別名
  • Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic .ALPHA.1B-Receptor Blockade but Not by .ALPHA.1A-Blockade.
  • Periarterial Electrical Nerve Stimulation Induced Adrenergic Vasoconstriction Inhibited by Adrenergic アルファ 1B Receptor Blockade but Not by アルファ 1A Blockade

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The periarterial electrical nerve stimulation at a frequency of 4 Hz (30-s trains of pulses) induced a double-peaked vasoconstriction in the canine splenic artery. The treatment with chloroethylclonidine (CEC, 60 μM) markedly inhibited the second-peaked constriction, whereas it produced an insignificant effect on the first-peaked response. The vasoconstriction to noradrenaline (NA, 1 nmol) was not significantly influenced by 60 μM CEC. On the other hand, WB 4101 (1 μM) consistently abolished the vascular response induced by NA (1 nmol), but rather potentiated the double-peaked constriction. The results indicate that neuronal NA may junctionally exert its vasoconstrictor effect via an activation of postjunctional α1B-receptors, whereas exogenous NA may extrajunctionally activate α1A-receptors for its vascular action in the canine splenic artery.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (3), 360-362, 2000

    公益社団法人 日本薬理学会

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