Contribution of NMDA Receptors to Activity of Augmenting Expiratory Neurons in Vagotomized Cats.

DOI Web Site Web Site Web Site Web Site View 1 Remaining Hide 29 References
  • Haji Akira
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
  • Okazaki Mari
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
  • Takeda Ryuji
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan

Bibliographic Information

Other Title
  • Contribution of NMDA Receptors to Activity of Augmenting Epiratory Neurons in Vagotomized Cats

Search this article

Abstract

To identify the NMDA receptor-mediated mechanism in augmenting expiratory(E2)neurons, the effects of systemic and local application of dizocilpine on spontaneous and evoked postsynaptic potentials(PSPs)were investigated in decerebrate and vagotomized cats.Intravenously applied dizocilpine reduced the inhibitory PSPs during inspiration and stage 1 expiration, but had little effect on the excitatory PSPs during stage 2 expiration.Iontophoresed dizocilpine caused a continuous hyperpolarization throughout the respiratory cycle.Dizocilpine had no effect on vagally evoked PSPs.These results suggest that the NMDA mechanisms are involved presynaptically in periodic postsynaptic inhibitions and postsynaptically in tonic excitation in E2 neurons.

Journal

References(29)*help

See more

Keywords

Report a problem

Back to top