【4/18更新】CiNii ArticlesのCiNii Researchへの統合について

Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats.

  • Aikawa Nobuo
    Drug Development Research Laboratories,Pharmaceutical Research Institute,Kyowa Hakko Kogyo Co.,Ltd.,1188 Shimotogari,Nagaizumi-cho,Sunto-gun,Shizuoka 411-8731,Japan
  • Ohmori Kenji
    Drug Development Research Laboratories,Pharmaceutical Research Institute,Kyowa Hakko Kogyo Co.,Ltd.,1188 Shimotogari,Nagaizumi-cho,Sunto-gun,Shizuoka 411-8731,Japan

この論文をさがす

抄録

The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug.5-Hydroxytryptamine(10mg/kg, s.c.), neostigmine(0.3mg/kg, s.c.)and nicotine(1.0mg/kg, s.c.)increased fecal pellet output.Zaldaride(≥30mg/kg, p.o.)reduced these increases in facal pellet outputs.Loperamide(10mg/kg, p.o.)inhibited fecal pellet output induced by 5-hydroxytryptamine and neostigmine but not nicotine.Under normal conditions, zaldaride and loperamide did not affect fecal pellet output at doses used in these studies.In conclusion, zaldaride may inhibit increases in fecal pellet output induced by hyperpropulsion of the gastrointestinal tract without causing constipation as a side effect.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (4), 350-352, 2000

    公益社団法人 日本薬理学会

被引用文献 (0)*注記

もっと見る

参考文献 (16)*注記

もっと見る

関連論文

もっと見る

関連研究データ

もっと見る

関連図書・雑誌

もっと見る

関連博士論文

もっと見る

関連プロジェクト

もっと見る

関連その他成果物

もっと見る

詳細情報

問題の指摘

ページトップへ