Influence of Lactation on Plasma Phenobarbital Concentrations in Rats.
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- Moriyama Masahiro
- Department of Hospital Pharmacy, Okayama University Medical School
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- Yamashita Syoichi
- Department of Hospital Pharmacy, Okayama University Medical School
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- Furuno Katsushi
- Department of Hospital Pharmacy, Okayama University Medical School
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- Sato Tomoaki
- Department of Hospital Pharmacy, Faculty of Medical Sciences
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- Domoto Haruyo
- Department of Hospital Pharmacy, Okayama University Medical School
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- Yamatogi Yasuko
- Child Neurology, Okayama University Medical School
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- Kawasaki Hiromu
- Department of Hospital Pharmacy, Okayama University Medical School
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- Gomita Yutaka
- Department of Hospital Pharmacy, Okayama University Medical School
Bibliographic Information
- Other Title
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- Influence of Lactation on Plasma Phenob
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Abstract
The effect of lactation on the pharmacokinetics of phenobarbital (PB) after delivery was studied in female rats. Non-pregnant animals received PB 20 mg/kg/day twice for 6-7 days before mating, during pregnancy and after delivery. Chronic PB did not significantly influence changes in the body weight of rats after delivery. On the first post-delivery day, the plasma PB concentration in the PB-treated rats was significantly higher than that in PB-treated, non-pregnant rats (non-pregnant rats); and thereafter, it gradually decreased until ablactation on the 20th day. After ablactation, plasma PB concentrations gradually returned to the level before delivery. In PB-treated rats, pharmacokinetic parameters (Cmax, AUC0-12)of PB between 0 and 12 hr after a single oral administration were significantly decreased during lactation. These results suggest that PB administered during lactation is transferred in part to offspring through maternal milk.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 73 (3), 191-196, 1997
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679264555776
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- NII Article ID
- 10008677330
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXitFKqt70%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4196913
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- PubMed
- 9127813
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- Web Site
- http://id.ndl.go.jp/bib/4196913
- https://ndlsearch.ndl.go.jp/books/R000000004-I4196913
- https://api.elsevier.com/content/article/PII:S002151981933820X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981933820X?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1997146026
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed